Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus

Immunogenetics. 1984;20(4):433-42. doi: 10.1007/BF00345617.


Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked carbohydrates, probably present as one N-linked glycan. The presumed analogue of beta 2-microglobulin has a molecular weight of 13 000 and bears no asparagine-linked glycans. Family studies show that the heavy chains are encoded by genes residing in or closely linked to the MHC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Erythrocytes / immunology
  • Glycoproteins / immunology
  • Histocompatibility Antigens / genetics*
  • Histocompatibility Antigens / immunology
  • Hybridization, Genetic
  • Isoelectric Point
  • Leukocytes / immunology
  • Major Histocompatibility Complex*
  • Molecular Weight
  • Xenopus / immunology*


  • Glycoproteins
  • Histocompatibility Antigens