Risk factors for drug allergy

J Allergy Clin Immunol. 1984 Oct;74(4 Pt 2):567-72. doi: 10.1016/0091-6749(84)90108-8.


Judging from available data on penicillin allergy there appear to be multiple definable risk factors for drug-induced immunopathology. The induction of a drug-specific immune response can be influenced by the age of the patient; underlying genetic or metabolic factors, which may restrict ability to initiate a drug-specific immune response; the chemical properties of the drug, largely its protein reactivity; and the dose and duration of treatment as well as the route of drug administration. The elicitation of drug-induced immunopathology is a function of the persistence of a drug-specific immune response; the frequency of drug treatment and its dose and duration; and probable constitutional factors that may determine in an important way the efficiency with which a drug-specific immune response can be translated into a systemic allergic reaction.

MeSH terms

  • Age Factors
  • Antibody Formation
  • Dose-Response Relationship, Drug
  • Drug Hypersensitivity / genetics
  • Drug Hypersensitivity / immunology*
  • Humans
  • Immunoglobulin E / immunology
  • Longitudinal Studies
  • Penicillins / adverse effects
  • Risk
  • Time Factors


  • Penicillins
  • Immunoglobulin E