Nitrogen mustard (mechlorethamine) and UVB photocarcinogenesis: a dose response effect

J Invest Dermatol. 1984 Nov;83(5):320-2. doi: 10.1111/1523-1747.ep12264105.


The effects of UVB energy and nitrogen mustard (mechlorethamine, HN2) on tumor formation in the hairless mouse skin was examined. Twice weekly applications of HN2 produced tumors in 34% of the mice. In addition, the HN2 treatments plus UVB radiation resulted in a significant acceleration in tumor formation as compared to either carcinogenic stimulus alone. The twice weekly application of HN2 plus UVB exposure was more tumorigenic than UVB plus HN2 applied once a week. Thus a positive carcinogenic dose response was noted. No tumor-suppressing effects were detected in this study.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / chemically induced
  • Carcinoma, Squamous Cell / etiology*
  • Dose-Response Relationship, Drug
  • Mechlorethamine / administration & dosage
  • Mechlorethamine / adverse effects*
  • Mice
  • Mice, Hairless
  • Neoplasms, Radiation-Induced / etiology*
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / etiology*
  • Ultraviolet Rays / adverse effects*


  • Mechlorethamine