Glycosylated hemoglobin as a screening test for carbohydrate intolerance in pregnancy

Am J Obstet Gynecol. 1984 Nov 1;150(5 Pt 1):455-60. doi: 10.1016/s0002-9378(84)90420-4.

Abstract

The usefulness of glycosylated hemoglobin as a prenatal screening test for carbohydrate intolerance was studied in 806 consecutive subjects by correlating glycosylated hemoglobin to 1-hour post-50 gm Glucola plasma glucose (1 degree G) levels, and 3-hour oral glucose tolerance tests (3 degrees GTT). Sixty-seven subjects whose 1 degree G greater than or equal to 150 mg/100 ml received a 3 degrees GTT; 12 were diagnostic of carbohydrate intolerance. Compared to carbohydrate-tolerant controls, carbohydrate-intolerant gravid patients had higher 1 degree G (p less than 0.001) and glycosylated hemoglobin (p less than 0.05) levels. Linear regression analysis of 1 degree G and glycosylated hemoglobin demonstrated r = 0.35 (p less than 0.0001). Compared to the glycosylated hemoglobin test, the 1 degree G screening test has greater specificity, sensitivity, and predictive value for a positive diagnosis. Consequently, the 1 degree G is a better routine screening test for carbohydrate intolerance than is glycosylated hemoglobin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus / diagnosis*
  • Evaluation Studies as Topic
  • Female
  • Glucose Tolerance Test
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Regression Analysis

Substances

  • Glycated Hemoglobin A