Color as a risk factor in iris melanoma

Am J Ophthalmol. 1984 Nov;98(5):558-61. doi: 10.1016/0002-9394(84)90240-x.


We reviewed 23 iris melanomas for iris color and gross tumor pigmentation. Patients with iris melanoma had lighter irides than both population controls (x2 = 58.0; P less than .0001) and other patients with uveal melanoma (x2 = 17.1; P = .002). Amelanotic and lightly melanotic tumors occurred predominantly in the patients with light irides.

MeSH terms

  • Eye Color*
  • Humans
  • Iris Diseases / etiology*
  • Melanoma / etiology*
  • Risk
  • Uveal Neoplasms / etiology*