Atopic allergy and serum IgE concentrations in randomly selected children followed up from 8 to 12 years of age

Allergy. 1984 Aug;39(6):443-50. doi: 10.1111/j.1398-9995.1984.tb01966.x.


A total of 159 children selected at random were followed up from the age of 8 to 12 years regarding the development and cumulated incidence of atopic disease as well as serum IgE concentrations. The cumulated incidence, including healed cases, rose to 25.8%. The highest prevalence was found for allergic rhinitis (12.2%). Serum IgE concentrations decreased significantly in both healthy and atopic subjects, and indicated a peak in total IgE concentration in early school age. The allergy predictive value of elevated IgE concentrations was confirmed. Low concentrations of allergen-specific IgE were found in 14.1% of children healthy before and during the observation period, indicating that transient production of IgE antibodies is a normal phenomenon. Finally, the stability of IgE was excellent during the first 2 years at -20 degrees C but later on concentrations tended to decrease, especially in the lower range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Child
  • Follow-Up Studies
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Immunoglobulin E / analysis*
  • Pollen
  • Radioallergosorbent Test
  • Rhinitis, Allergic, Perennial / immunology


  • Immunoglobulin E