A statistical method for determining the breakpoint of two lines

Anal Biochem. 1984 Aug 15;141(1):287-90. doi: 10.1016/0003-2697(84)90458-5.


A method is presented for determining the breakpoint of a line which suddenly changes slope at some unknown point. A statistical test is given for testing whether the broken line is a significantly better fit to the data than a single straight line. An approximate confidence interval can be obtained for the position of the breakpoint.

MeSH terms

  • Alkaline Phosphatase / analysis
  • Chemical Phenomena
  • Chemistry
  • Computers
  • Kidney Cortex / enzymology
  • Statistics as Topic*


  • Alkaline Phosphatase