[Effect of sodium succinate on metabolic and morphological changes in acute cooling]

Biull Eksp Biol Med. 1984 Oct;98(10):420-2.
[Article in Russian]

Abstract

The effect of sodium succinate preinjection (16 mg/kg) on the resistance of mice to acute low-temperature exposure was studied. The measurements were taken of the changes in blood glucose concentration, of the content in the heart of macroergic compounds and glycogen, and of succinate dehydrogenase activity. Cardiomyocytes were studied by electron microscopy. The data indicate that greater preservation of macroergic compounds and stabilization of the ultrastructure of myocardial mitochondria play a role in the mechanism by which the animals' resistance to intense cooling is increased after sodium succinate injection.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Animals
  • Cold Temperature / adverse effects
  • Drug Evaluation, Preclinical
  • Energy Metabolism / drug effects*
  • Hypothermia / drug therapy*
  • Hypothermia / physiopathology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Myocardium / metabolism
  • Myocardium / ultrastructure
  • Succinates / therapeutic use*
  • Succinic Acid
  • Time Factors

Substances

  • Succinates
  • Succinic Acid