A combination of cefuroxime and N-acetyl-cysteine for the treatment of maxillary sinusitis in children with respiratory allergy

Int J Clin Pharmacol Ther Toxicol. 1984 Sep;22(9):511-4.


Twenty-four atopic children with allergic rhinitis, asthma and maxillary sinusitis were treated with a combination of cefuroxime 50-80 mg/kg/day and N-acetyl-cysteine 15-25 mg/kg/day administered intramuscularly for 10 days. The efficacy of the treatment was judged on the basis of radiological and clinical evolution. The treatment was effective in 95.8% of the children, and 37.5% of them were able to reduce their treatment for asthma. None of the patients suffered severe side effects. The data obtained confirm that appropriate treatment of the sinusitis frequently results in a significant improvement of the asthmatic condition.

MeSH terms

  • Acetylcysteine / therapeutic use*
  • Adolescent
  • Asthma / complications
  • Asthma / therapy
  • Cefuroxime / therapeutic use*
  • Cephalosporins / therapeutic use*
  • Child
  • Chronic Disease
  • Drug Therapy, Combination
  • Humans
  • Maxillary Sinus
  • Respiratory Hypersensitivity / complications
  • Respiratory Hypersensitivity / therapy*
  • Sinusitis / complications
  • Sinusitis / drug therapy*


  • Cephalosporins
  • Cefuroxime
  • Acetylcysteine