Microtubule assembly nucleated by isolated centrosomes

Nature. 1984 Nov 15-21;312(5991):232-7. doi: 10.1038/312232a0.


Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell-Free System
  • Centrioles / ultrastructure*
  • Mice
  • Microtubules / physiology*
  • Microtubules / ultrastructure
  • Morphogenesis
  • Polymers
  • Protein Binding
  • Tubulin / physiology*


  • Polymers
  • Tubulin