Effects of verapamil and nifedipine on renal function and hemodynamics in the dog

Ren Physiol. 1984;7(6):329-43. doi: 10.1159/000172955.


This study evaluates the direct effects of verapamil (5 micrograms/kg/min) or nifedipine (0.32 micrograms/kg/min) when infused into one renal artery for 2 h. The role of calcium in the systemic and renal vascular effects of angiotensin II (1 microgram/i.v. bolus) was examined in each period. Renal blood flow was increased 11% by verapamil and 29% by nifedipine. Unlike other vasodilators, these drugs markedly increased GFR (by 75% with verapamil and 50% with nifedipine), and both caused a profound natriuresis, which outlasted the renal hemodynamic changes. Further, they abolished the renal vascular responses to angiotensin II. These major direct effects on renal function and hemodynamics suggest that: (a) calcium blockers may affect the determinants of GFR differently from other vasodilators, and (b) they may interfere with proximal tubular Na+ transport.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Angiotensin II / antagonists & inhibitors
  • Angiotensin II / pharmacology
  • Animals
  • Dogs
  • Female
  • Glomerular Filtration Rate / drug effects
  • Hemodynamics / drug effects
  • Kidney / blood supply
  • Kidney / drug effects*
  • Male
  • Nifedipine / pharmacology*
  • Verapamil / pharmacology*


  • Angiotensin II
  • Verapamil
  • Nifedipine