A fresh look at iontophoresis

Arch Ophthalmol. 1984 Dec;102(12):1825-9. doi: 10.1001/archopht.1984.01040031483028.

Abstract

The rate of penetration of fluorescein and gentamicin ions into the anterior chamber of the rabbit was increased more than 100-fold by the passage of 1 mamp; the amount of drug that penetrates is better controlled by iontophoresis than by instillation. The potential value, the safety and the limitations of this procedure are discussed, and a theoretical basis for the increase is provided. Practical methods of using iontophoresis in the clinic are described. A 30-s application should result in a therapeutic level of the antibiotic in the anterior segment over a 12-hour period in eyes with an intact epithelium.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anterior Chamber / analysis
  • Anterior Chamber / metabolism
  • Aqueous Humor / analysis
  • Aqueous Humor / metabolism
  • Cornea / analysis
  • Cornea / metabolism
  • Female
  • Fluorescein
  • Fluoresceins / analysis
  • Fluoresceins / metabolism
  • Gentamicins / analysis
  • Gentamicins / metabolism
  • Humans
  • Iontophoresis* / adverse effects
  • Iontophoresis* / methods
  • Models, Theoretical
  • Permeability
  • Rabbits
  • Risk

Substances

  • Fluoresceins
  • Gentamicins
  • Fluorescein