Neuropharmacological evidence to suggest that the nucleus accumbens and subpallidal region contribute to exploratory locomotion

Behav Neural Biol. 1984 Sep;42(1):52-60. doi: 10.1016/s0163-1047(84)90424-2.


Rats showed a substantial increase in locomotor activity when novel objects were introduced into an open-field apparatus. This exploratory locomotion was reduced significantly when glutamic acid diethyl ester HCl, a glutamate antagonist, was injected bilaterally into the nucleus accumbens or when gamma-aminobutyric acid was injected bilaterally into the subpallidal region. These observations provide preliminary support for a contribution of the nucleus accumbens and subpallidal region to exploratory locomotion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Exploratory Behavior / drug effects*
  • Globus Pallidus / drug effects*
  • Glutamates / pharmacology*
  • Male
  • Motor Activity / drug effects*
  • Neural Pathways / drug effects
  • Nucleus Accumbens / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Septal Nuclei / drug effects*
  • gamma-Aminobutyric Acid / pharmacology*


  • Glutamates
  • glutamic acid diethyl ester
  • gamma-Aminobutyric Acid