Silicon compounds as substrates and inhibitors of acetylcholinesterase

Biochim Biophys Acta. 1984 Dec 7;791(2):278-80. doi: 10.1016/0167-4838(84)90020-7.

Abstract

Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. The silicon compounds have kinetic parameters similar to those of their carbon analogues, except for trimethylsilylmethyl acetate, which is a substrate of acetylcholinesterase, whereas its carbon analogue is not susceptible to enzymic hydrolysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding, Competitive
  • Cholinesterase Inhibitors / metabolism*
  • Kinetics
  • Silicon / metabolism*
  • Trimethylsilyl Compounds / metabolism*
  • Trimethylsilyl Compounds / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Trimethylsilyl Compounds
  • 2-(trimethylsilyl)ethyl acetate
  • 2-(trimethylsilyl)ethanol
  • 2-(trimethylsilyl)methyl acetate
  • Silicon