Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea

Cancer Lett. 1984 Dec;25(2):117-21. doi: 10.1016/s0304-3835(84)80035-x.

Abstract

Piroxicam, a non-steroidal anti-inflammatory agent, was administered in the feed to rats which had been inoculated intra-rectally with N-methylnitrosourea (MNU). When examined 5 months later, the piroxicam-treated rats had a significant reduction of intestinal tumors compared to tumor incidences and tumor numbers in rats which were fed drug-free diet. There was no evidence of toxicity associated with the consumption of piroxicam.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Weight
  • Diet
  • Intestinal Neoplasms / chemically induced
  • Intestinal Neoplasms / drug therapy*
  • Male
  • Methylnitrosourea
  • Piroxicam
  • Rats
  • Rats, Inbred Strains
  • Thiazines / therapeutic use*

Substances

  • Thiazines
  • Piroxicam
  • Methylnitrosourea