Steroid Receptors in Intracranial Tumors

Clin Neuropharmacol. 1984;7(4):347-50. doi: 10.1097/00002826-198412000-00013.

Abstract

Cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors were evaluated in 6 meningiomas and 12 gliomas (6 astrocytomas and 6 glioblastomas) using a dextran-coated charcoal method. Thirty-three percent (two) of the meningiomas and 17% (two) of the gliomas contained positive (greater than or equal to 10 fmol/mg protein) but low ER levels. On the other hand, positive PR, GR, and AR levels were detectable in 100% (six) of the meningiomas. PR was present in 50% (six), AR in 42% (five), and GR in 58% (seven) of the gliomas. PR, GR, and AR values were statistically higher in meningiomas than in neuroepithelial tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brain Neoplasms / metabolism*
  • Child
  • Child, Preschool
  • Female
  • Glioma / metabolism
  • Humans
  • Kinetics
  • Male
  • Meningeal Neoplasms / metabolism
  • Meningioma / metabolism
  • Middle Aged
  • Receptors, Androgen / metabolism
  • Receptors, Estrogen / metabolism
  • Receptors, Glucocorticoid / metabolism
  • Receptors, Progesterone / metabolism
  • Receptors, Steroid / metabolism*

Substances

  • Receptors, Androgen
  • Receptors, Estrogen
  • Receptors, Glucocorticoid
  • Receptors, Progesterone
  • Receptors, Steroid