Interrelation between changes in the EEG and psychopathology under pharmacotherapy for endogenous depression. A contribution to the predictor question

Pharmacopsychiatry. 1984 Nov;17(6):178-83. doi: 10.1055/s-2007-1017433.


With the predictor problem in mind, we studied in-patients with endogenous depression whether relationships exist among the EEG, the therapeutic response, and the severity of psychopathology. We found that clinically defined responders and non-responders differ in respect of their average power spectra calculated for the two occipital regions. In addition, it was shown that there is a statistically significant correlation between the EEG before treatment and the severity of AMP-documented psychopathology after a 4-week treatment period. This correlation was stronger for the left occipital region than for the right.

Publication types

  • Comparative Study

MeSH terms

  • Amitriptyline / therapeutic use*
  • Antidepressive Agents / therapeutic use*
  • Carbazoles / therapeutic use*
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / psychology
  • Double-Blind Method
  • Evoked Potentials / drug effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales


  • Antidepressive Agents
  • Carbazoles
  • Amitriptyline
  • pirlindole