Third order linkage disequilibrium

Tissue Antigens. 1984 Oct;24(4):250-5. doi: 10.1111/j.1399-0039.1984.tb02134.x.


For third order linkage disequilibrium there is a constraint on the maximum value the disequilibrium can take, given pairwise disequilibria values and allele frequencies. As distinct from second order disequilibrium (considered in the context of a two locus model) there is also in some cases a constraint on the minimum value. The appropriate procedures to determine these maximum and minimum values are given, as well as numerical values utilizing HLA data.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Gene Frequency
  • Genetic Linkage*
  • HLA Antigens / genetics
  • Humans
  • Models, Genetic*
  • Statistics as Topic


  • HLA Antigens