Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover

Neuropharmacology. 1984 Oct;23(10):1223-5. doi: 10.1016/0028-3908(84)90244-2.

Abstract

The 5HT-mediated contraction of rat thoracic aorta is competitively blocked by the specific receptor antagonist 5HT2 ketanserin. In this tissue the addition of 5HT activated the turnover of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT2 recognition sites appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Aorta / drug effects
  • Aorta / physiology*
  • Hydrolysis
  • Ketanserin
  • Male
  • Phosphatidylinositols / metabolism*
  • Phospholipases / metabolism*
  • Piperidines / pharmacology
  • Rats
  • Receptors, Serotonin / physiology*
  • Serotonin / metabolism*
  • Type C Phospholipases / metabolism*
  • Vasoconstriction

Substances

  • Phosphatidylinositols
  • Piperidines
  • Receptors, Serotonin
  • Serotonin
  • Ketanserin
  • Phospholipases
  • Type C Phospholipases