[Dosage interval and in vivo action of penicillin against pneumococci]

Abstract

The relationship between dosage intervals of penicillin and bactericidal efficacy was investigated in an experimental model using normal and granulocytopenic mice and Streptococcus pneumoniae. Pulsdosing at 4-hour intervals proved to be significantly less efficient than fractional doses of the same total amount of penicillin injected at 1-hour intervals.