The acute oral and intravenous toxicity of p-aminopropiophenone (PAPP) to laboratory rodents

Toxicol Lett. 1984 Dec;23(3):359-65. doi: 10.1016/0378-4274(84)90034-1.

Abstract

The acute toxicity of p-aminopropiophenone (PAPP) to three species of laboratory animals has been investigated using solutions in dimethylsulphoxide (DMSO) for intravenous and oral (intragastric) administration. In addition, methaemoglobinaemia and Heinz-body haemolytic anaemia are described.

MeSH terms

  • Administration, Oral
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Guinea Pigs
  • Heinz Bodies / drug effects
  • Injections, Intravenous
  • Lethal Dose 50
  • Male
  • Methemoglobinemia / chemically induced
  • Mice
  • Propiophenones / administration & dosage
  • Propiophenones / toxicity*
  • Rats
  • Time Factors

Substances

  • Propiophenones
  • 4-aminopropiophenone