Acute self-poisoning with tricyclic antidepressants in 295 consecutive patients treated in an ICU

Acta Anaesthesiol Scand. 1984 Dec;28(6):666-70. doi: 10.1111/j.1399-6576.1984.tb02142.x.

Abstract

Clinical findings on admission to hospital and outcome in 295 consecutive patients with severe tricyclic antidepressant self-poisoning treated in an ICU are presented. Cerebral depression was observed in 92%, convulsions in 23% and respiratory failure was present in 72%. Cardiovascular function was impaired in 44% and an abnormal ECG was found in 57%. Cardiac arrest was treated in 14 patients (6%) of whom seven were resuscitated. The mortality rate was 2%. All patients were artificially ventilated. A beneficial effect of respiratory alkalosis on cardiac arrhythmias is supported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents
  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Antidepressive Agents, Tricyclic / poisoning*
  • Arrhythmias, Cardiac / chemically induced
  • Body Temperature / drug effects
  • Child
  • Coma / chemically induced
  • Critical Care
  • Female
  • Heart Arrest / chemically induced
  • Humans
  • Male
  • Middle Aged
  • Respiratory Insufficiency / chemically induced
  • Seizures / chemically induced
  • Shock / chemically induced
  • Suicide, Attempted

Substances

  • Antidepressive Agents, Tricyclic