Ascorbic acid supplementation and five year survival rates in women with early breast cancer

Acta Vitaminol Enzymol. 1984;6(3):175-82.


The effect of long term ascorbic acid (AA) supplementation (3g per day) on 27 women with early breast cancer has been investigated. For comparison a similar but limited study was carried out in patients with benign breast disease. The responses of leucocyte levels of AA to supplementation provided some evidence to suggest that the metabolism and utilisation of the vitamin may be different in these patients. In addition longitudinal measurements of urinary hydroxyproline/creatinine (OHPro/Cr) ratio were carried out in these patients. The long term ingestion of AA did not appear to affect the prognosis of the disease in the early breast cancer group. Similar 5 year survival rates were seen in the unsupplemented and supplemented cancer groups.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Ascorbic Acid / blood
  • Ascorbic Acid / metabolism
  • Ascorbic Acid / therapeutic use*
  • Breast Diseases / drug therapy*
  • Breast Diseases / metabolism
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Creatinine / urine
  • Female
  • Humans
  • Hydroxyproline / urine
  • Longitudinal Studies
  • Middle Aged
  • Neoplasm Recurrence, Local / prevention & control
  • Prognosis


  • Creatinine
  • Ascorbic Acid
  • Hydroxyproline