Malignant transformation of an optic nerve melanocytoma

Can J Ophthalmol. 1984 Dec;19(7):320-5.


A 47-year-old woman who had had a flat, hyperpigmented lesion of the optic disc and juxtapapillary choroid for at least 17 years experienced acute visual loss. This was caused by rapid growth of a pigmented tumour emanating from the original lesion. Histopathological examination of the enucleated globe revealed a large malignant melanoma originating from a melanocytoma (magnocellular nevus) within the optic nerve and peripapillary choroid. This case represents a very rare instance of malignant transformation of a normally benign tumour.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic / pathology*
  • Cranial Nerve Neoplasms / diagnostic imaging
  • Cranial Nerve Neoplasms / pathology*
  • Female
  • Fundus Oculi
  • Hamartoma / diagnostic imaging
  • Hamartoma / pathology*
  • Humans
  • Melanocytes / pathology
  • Optic Nerve*
  • Tomography, X-Ray Computed