Pharmacokinetics of vinpocetine (Cavinton) in dog

Pol J Pharmacol Pharm. 1984 Jul-Aug;36(4):407-12.

Abstract

The pharmacokinetics of vinpocetine after 10 mg po and iv doses was studied in six beagle dogs treated in cross-over design. The concentration of the drug in plasma was determined by gas-liquid chromatography using N-P FID and capillary column. The elimination half-live and clearance values calculated from time plasma concentration data for iv administration were 8.9 +/- 2.87 h and 4.2 +/- 1.06 1/kg/h, respectively. The bioavailability of the drug was found to be 21.5 +/- 19.3%.

MeSH terms

  • Administration, Oral
  • Animals
  • Dogs
  • Female
  • Half-Life
  • Injections, Intravenous
  • Kinetics
  • Male
  • Vasodilator Agents / metabolism*
  • Vinca Alkaloids / metabolism*

Substances

  • Vasodilator Agents
  • Vinca Alkaloids
  • vinpocetine