Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

Diabetologia. 1984 Dec;27(6):604-6. doi: 10.1007/BF00276978.


Cyclophosphamide promoted the onset of overt diabetes in non-obese diabetes-prone mice of both sexes. Two injections of this agent at 2 weeks apart were necessary to obtain a constant high incidence, although even a single injection was effective in some animals. Clinical symptoms of the cyclophosphamide-induced diabetes were similar to those of the naturally occurring type. The same schedule of cyclophosphamide treatment failed to induce diabetes in non-diabetic mouse strains, such as DS/Shi,Jcl:ICR or in non-obese non-diabetes-prone mice, which suggests that the promotion of diabetes by cyclophosphamide in non-obese diabetes-prone mice is not due to the simple pharmacological action of this agent but to some immunopharmacological action.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cyclophosphamide / pharmacology*
  • Diabetes Mellitus, Experimental / genetics*
  • Diabetes Mellitus, Experimental / physiopathology
  • Female
  • Mice
  • Mice, Inbred Strains
  • Species Specificity
  • Time Factors


  • Cyclophosphamide