Effect of omeprazole, a substituted benzimidazole, on 24-h intragastric acidity in patients with peptic ulcer disease

Scand J Gastroenterol. 1984 Oct;19(7):916-22.


Intragastric pH was measured during physiological conditions over 24-h periods in patients with peptic ulcer disease. After single oral doses of 20, 40, and 80 mg omeprazole we found a dose-dependent reduction in mean intragastric acidity ranging from 38% to 99%. After treatment for 1 week with omeprazole, 40 mg daily, with or without an initial loading dose of 80 mg, intragastric acidity was decreased by more than 99%. This is a more pronounced decrease in acidity than can be achieved even with very high doses of histamine H2-receptor antagonists.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Ulcer Agents / therapeutic use*
  • Benzimidazoles / administration & dosage
  • Benzimidazoles / therapeutic use*
  • Circadian Rhythm
  • Dose-Response Relationship, Drug
  • Duodenal Ulcer / drug therapy*
  • Female
  • Gastric Acid / metabolism*
  • Gastric Acidity Determination
  • Humans
  • Male
  • Middle Aged
  • Omeprazole
  • Secretory Rate / drug effects
  • Stomach Ulcer / drug therapy*


  • Anti-Ulcer Agents
  • Benzimidazoles
  • Omeprazole