Clinical features, scintiscan characteristics and X-ray progression of late onset rheumatoid arthritis

Clin Exp Rheumatol. Apr-Jun 1984;2(2):157-61.

Abstract

The clinical features, serology behaviour, scintiscan characteristics and the degree of X-ray progression according to the disease duration were compared in two RA groups with a disease onset after 65 years of age (LORA) and before 65 (EORA) respectively. No differences emerged in either the clinical findings or in the scintiscan picture. A sub-group of LORA showed acute flares of the illness presenting with very high ESR values and high fever. The erosive index (EI) evaluated in three areas (carpal-bone and wrist, MCP and PIP joints) revealed an undistinguishable degree of X-ray damage either in seropositive or seronegative patients, whereas seropositive EORA fared clearly worse than seronegative ones. A prospective study in two small sub-groups of LORA and EORA revealed a progression of X-ray erosions despite second line drug treatment in both groups, especially in LORA.

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / classification
  • Arthritis, Rheumatoid / diagnostic imaging
  • Arthritis, Rheumatoid / physiopathology*
  • Blood Sedimentation
  • C-Reactive Protein / analysis
  • Female
  • Gold / therapeutic use
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Radiography
  • Radionuclide Imaging
  • Time Factors
  • Tiopronin / therapeutic use

Substances

  • Hydroxychloroquine
  • Gold
  • C-Reactive Protein
  • Tiopronin
  • Methylprednisolone