Corneal endothelial changes after argon laser iridotomy

Am J Ophthalmol. 1984 Aug 15;98(2):153-6. doi: 10.1016/0002-9394(87)90349-7.


We used a continuous-wave argon laser to produce iridotomies in 28 eyes of 17 patients (12 women and five men ranging in age from 44 to 84 years) with angle-closure glaucoma. We photographed the central corneal endothelium with a contact specular microscope before and after the laser iridotomy was produced. The mean number of cells before treatment was 2,516 cells/mm2 and the mean number after treatment was 2,391 cells/mm2. The mean decrease, therefore, was 125 cells/mm2. This decrease was not statistically significant (P = .09). Retrogression analysis failed to show a correlation between the amount of energy necessary to produce the iridotomy and a decrease in endothelial cell density. Retrogression analysis also failed to show a correlation between the change in endothelial cell density and the time between the laser iridotomy and the performance of postoperative specular microscopy (one to 41 weeks).

MeSH terms

  • Adult
  • Aged
  • Argon
  • Cell Count
  • Cornea / pathology*
  • Corneal Diseases / etiology
  • Corneal Diseases / pathology
  • Endothelium / pathology
  • Female
  • Glaucoma / surgery*
  • Humans
  • Iris / surgery*
  • Laser Therapy*
  • Lasers / adverse effects*
  • Male
  • Middle Aged


  • Argon