Age differences in cisplatinum nephrotoxicity

Toxicology. 1984 Sep 28;32(4):343-53. doi: 10.1016/0300-483x(84)90086-6.

Abstract

Male and female Wistar rats (5-105-day-old) were administered 3 different doses of cisplatinum (CP) (0.15, 0.3 or 0.6 mg/100 g body wt, intraperitoneally) After 3 days the renal excretory functions were investigated. There were no sex differences in nephrotoxicity. In rats of all age groups a dose dependent decrease in body weight appeared. In 5- and 33-105-day-old rats the 2 lower doses did not or only mildly influence renal function. 0.6 mg CP/100 g body wt in these age groups lead to a significant reduction in urine volume. The excretion of osmotically active substances and p-aminohippurate were reduced. There is a statistically significant proteinuria. In 10- and 15-day-old rats the 2 lower doses were without any pathologic consequences, but 0.6 mg CP/100 g body wt was followed by a significant increase in the protein excretion of 15-day-old rats. Consequently, regarding the parameters measured 10-15-day-old rats seemed to be less susceptible to CP-nephrotoxicity.

MeSH terms

  • Aging*
  • Animals
  • Body Weight / drug effects
  • Cisplatin / toxicity*
  • Female
  • Injections, Intraperitoneal
  • Kidney / drug effects*
  • Lethal Dose 50
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sex Factors
  • p-Aminohippuric Acid / urine

Substances

  • Cisplatin
  • p-Aminohippuric Acid