Baculovirus replication: effects of inhibitors of macromolecular synthesis

J Antimicrob Chemother. 1984 Aug;14 Suppl A:43-55. doi: 10.1093/jac/14.suppl_a.43.

Abstract

A number of inhibitors of DNA, RNA, protein and polyamine synthesis have been used to elucidate the mode of replication of baculoviruses. An overview of the viruses, the antimicrobial inhibitors used, and the effects of the drugs are presented. Although certain inhibitors of protein synthesis and DNA synthesis are useful in determining the program of expression of the viral genome into immediate early, delayed early, late and very late phases of synthesis, few drugs have proved useful as antimicrobial agents. Bromovinyldeoxyuridine (BVDU) is a potent inhibitor of baculovirus replication inhibiting viral DNA synthesis by blocking the virus induced DNA polymerase. Preliminary experiments suggest that BVDU suppresses baculovirus disease in insect larvae.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cytoskeleton / drug effects
  • DNA Viruses / drug effects*
  • DNA Viruses / metabolism
  • DNA Viruses / ultrastructure
  • DNA, Viral / biosynthesis
  • Insect Viruses / drug effects*
  • Insect Viruses / metabolism
  • Insect Viruses / ultrastructure
  • Polyamines / metabolism
  • RNA, Viral / biosynthesis
  • Viral Proteins / biosynthesis
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • DNA, Viral
  • Polyamines
  • RNA, Viral
  • Viral Proteins