Cytidine(5')diphosphocholine enhances the ability of haloperidol to increase dopamine metabolites in the striatum of the rat and to diminish stereotyped behavior induced by apomorphine

Neuropharmacology. 1984 Dec;23(12A):1403-6. doi: 10.1016/0028-3908(84)90080-7.


Experiments were performed to determine whether exogenous cytidine(5')diphosphocholine (CDP-choline) could modify release of dopamine in the striatum and behavior dependent on dopamine, perhaps by providing supplemental choline for synthesis of acetylcholine. Rats received water (control) or CDP-choline orally (100 mg/kg per day, for 5 days), either alone or before injection with haloperidol (1 mg/kg, i.p.), apomorphine (0.15 mg/kg, s.c.), or both. Stereotyped behavior was measured during the hour after administration of apomorphine; levels of the dopamine metabolites, homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum were assessed at the end of this period (2 hr after administration of haloperidol). In rats receiving the CDP-choline, the stereotyped behavior observed after injection of apomorphine alone (P less than 0.01), or after haloperidol plus apomorphine (P less than 0.01), was attenuated. The pretreatment with CDP-choline also significantly increased levels of HVA (by 24%) and DOPAC (by 23%) in the striatum over appropriate controls in animals receiving haloperidol, or by 29 and 59% (averaging data for all time points), respectively, in animals receiving haloperidol plus apomorphine. One mechanism by which CDP-choline may affect behavior involves contributing choline to enhance synthesis of acetylcholine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Apomorphine / antagonists & inhibitors*
  • Choline / analogs & derivatives*
  • Corpus Striatum / metabolism*
  • Cytidine Diphosphate Choline / pharmacology*
  • Dopamine / metabolism*
  • Drug Synergism
  • Haloperidol / pharmacology*
  • Homovanillic Acid / metabolism
  • Humans
  • Male
  • Rats
  • Rats, Inbred Strains
  • Stereotyped Behavior / drug effects*


  • 3,4-Dihydroxyphenylacetic Acid
  • Cytidine Diphosphate Choline
  • Haloperidol
  • Apomorphine
  • Choline
  • Dopamine
  • Homovanillic Acid