Differences in the control of virus mRNA splicing during permissive or abortive infection with influenza A (fowl plague) virus

J Gen Virol. 1984 Jan;65 ( Pt 1):153-64. doi: 10.1099/0022-1317-65-1-153.

Abstract

Spliced transcripts of influenza A (fowl plague) virus (FPV) RNA (vRNA) segments 7 and 8 accumulate to a much greater extent during non-productive infection of mouse L cells, than they do during productive infection in primary chick embryo fibroblasts (CEF). Virus-specific protein synthesis, or a consequent event in virus replication appears necessary to promote splicing of vRNA segment 8-encoded mRNAs in both cell types, and of vRNA segment 7-encoded mRNAs in CEF. In L cells, however, splicing of the segment 7-encoded mRNAs seems to be independent of such virus-specific control. This observation is discussed in relation to the defect in expression of vRNA 7 which has been observed previously in FPV-infected L cells, and which is thought to account for the failure of virus replication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • DNA / genetics
  • DNA, Viral / genetics
  • Gene Expression Regulation
  • Influenza A virus / genetics*
  • L Cells / microbiology
  • Mice
  • Nucleic Acid Hybridization
  • Peptides / genetics
  • RNA Splicing*
  • RNA, Viral / genetics*
  • Viral Proteins / biosynthesis
  • Virus Cultivation
  • Virus Replication

Substances

  • DNA, Viral
  • Peptides
  • RNA, Viral
  • Viral Proteins
  • DNA