Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus

Appl Environ Microbiol. 1984 Jan;47(1):98-100. doi: 10.1128/aem.47.1.98-100.1984.

Abstract

Territrem C, a new tremorgenic mycotoxin (C28H32O9; molecular weight, 512.20) was isolated from the chloroform extract of rice cultures of Aspergillus terreus 23-1, which also produces territrems A and B. Isolation, acute toxicity, and some physicochemical properties of territrem C are discussed in this paper. The spectral and chemical evidence indicated that the structural difference between territrem C and territrem B (C29H34O9) was in their phenyl moieties: a 4-hydroxy-3,5-dimethoxy phenyl group in territrem C and a 3,4,5-trimethoxy phenyl group in territrem B. It was also demonstrated that territrem B was obtained by methylation of territrem C with dimethyl sulfate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspergillus / analysis*
  • Aspergillus / pathogenicity
  • Female
  • Male
  • Mice
  • Mice, Inbred ICR
  • Pyrans / isolation & purification*
  • Pyrans / toxicity

Substances

  • Pyrans
  • territrem A
  • territrem B
  • territrem C