Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

Nature. 1984 Mar 8-14;308(5955):153-8. doi: 10.1038/308153a0.


Comparison of the sequence of a cloned T cell-specific cDNA with those of cross-reacting cloned cDNAs isolated from a thymocyte library indicates the presence of variable, constant and joining regions remarkably similar in size and sequence to those encoding immunoglobulin proteins. Together with the evidence for somatic gene rearrangements reported in the accompanying paper, this strongly suggests that the TM86 cDNA clone encodes one chain of the T-cell receptor for antigen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular*
  • DNA / isolation & purification*
  • Genes*
  • Humans
  • Immunoglobulin Fragments / genetics
  • Immunoglobulin Variable Region / genetics
  • Immunoglobulins / genetics*
  • Mice
  • Receptors, Antigen, T-Cell / genetics*


  • Immunoglobulin Fragments
  • Immunoglobulin Variable Region
  • Immunoglobulins
  • Receptors, Antigen, T-Cell
  • DNA

Associated data

  • GENBANK/K01080
  • GENBANK/K01081
  • GENBANK/K01082
  • GENBANK/K01083