Neuromedin C: a bombesin-like peptide identified in porcine spinal cord

Biochem Biophys Res Commun. 1984 Feb 29;119(1):14-20. doi: 10.1016/0006-291x(84)91611-5.


From a side fraction obtained in our previous isolation of neuromedin B from porcine spinal cord, we have purified another decapeptide that exhibits a potent stimulant effect on the smooth muscle preparation of rat uterus. By microsequencing and synthesis, the amino acid sequence of the peptide has been identified as: Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. This peptide is found to be identical with the carboxy-terminal subsequence [18-27] of gastrin releasing peptide, and to display a potent contractile activity on rat uterus in the characteristic manner of bombesin. These facts strongly suggest that the peptide may be a neuromediator in the neural communication systems of mammals. We propose the name "neuromedin C" for this peptide, since it is closely related to "neuromedin B", recently identified as a bombesin-like mammalian peptide.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Assay
  • Bombesin / pharmacology
  • Chromatography, High Pressure Liquid
  • Female
  • Gastrin-Releasing Peptide
  • Guinea Pigs
  • Ileum / drug effects
  • Oligopeptides / isolation & purification
  • Oligopeptides / pharmacology*
  • Peptide Fragments
  • Peptides
  • Rats
  • Spinal Cord / analysis*
  • Structure-Activity Relationship
  • Swine
  • Uterine Contraction / drug effects


  • Oligopeptides
  • Peptide Fragments
  • Peptides
  • Gastrin-Releasing Peptide
  • neuromedin C
  • Bombesin