The structural basis of the multiple forms of human complement component C4

Cell. 1984 Apr;36(4):907-14. doi: 10.1016/0092-8674(84)90040-0.


cDNA clones of human complement components C4A and C4B alleles were prepared from mRNA obtained from the liver of a donor heterozygous at both loci. cDNA from one C4A allele was sequenced to give the derived complete amino acid sequence of 1722 amino acid residues of the C4 single chain precursor molecule and the estimated sequences of the three peptide chains of secreted C4. Comparison with partial sequences of a second C4A allele and a C4B allele has led to the tentative identification of some class differences in nucleotide sequences between C4A and C4B and of allelic differences between C4A alleles in this highly polymorphic system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular*
  • Complement C4 / genetics*
  • DNA / analysis
  • Heterozygote
  • Humans
  • Isoenzymes / genetics*
  • Liver / enzymology
  • Polymorphism, Genetic*
  • RNA, Messenger / genetics


  • Complement C4
  • Isoenzymes
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/K02403
  • GENBANK/K02404