Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells

Exp Cell Res. 1984 Jul;153(1):245-8. doi: 10.1016/0014-4827(84)90466-x.


Bombesin and the C-terminal portion of gastrin-releasing peptide (GRP14-27) each increase clonal growth rate and colony-forming efficiency of normal human bronchial epithelial cells. These effects occur in the presence or absence of an optimal concentration (5 ng/ml) of epidermal growth factor (EGF). In contrast to EGF bombesin and GRP14-27 do not stimulate cell migration. Thus, bombesin and the C-terminal fragment of gastrin-releasing peptide represent a new class of peptides mitogenic for normal human epithelial cells.

MeSH terms

  • Adult
  • Bombesin / pharmacology*
  • Bronchi / drug effects
  • Bronchi / physiology*
  • Cell Division / drug effects
  • Cells, Cultured
  • Clone Cells
  • Epithelium / drug effects
  • Epithelium / physiology
  • Gastrin-Releasing Peptide
  • Growth Substances / pharmacology*
  • Humans
  • Kinetics
  • Peptide Fragments / pharmacology*
  • Peptides / pharmacology*


  • Growth Substances
  • Peptide Fragments
  • Peptides
  • Gastrin-Releasing Peptide
  • gastrin releasing peptide (14-27)
  • Bombesin