Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord

Biochem Biophys Res Commun. 1984 Jul 31;122(2):542-9. doi: 10.1016/s0006-291x(84)80067-4.


A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to the COOH-terminal sequence of neurotensin. This structure has been confirmed by synthesis. Neuromedin N exhibits a contractile activity on guinea pig ileum and induces a hypotensive response in the rat similar to that with neurotensin. These findings suggest that neuromedin N may be a new neuromediator or hormone with a specific spectrum of biological activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Assay
  • Blood Pressure / drug effects
  • Chromatography, High Pressure Liquid
  • Guinea Pigs
  • Ileum / drug effects
  • Muscle Contraction / drug effects
  • Neurotensin / isolation & purification*
  • Neurotensin / pharmacology
  • Peptide Fragments / isolation & purification*
  • Peptide Fragments / pharmacology
  • Rats
  • Spinal Cord / analysis*
  • Structure-Activity Relationship
  • Swine


  • Peptide Fragments
  • neuromedin N
  • Neurotensin