Localization of the haptoglobin alpha and beta genes (HPA and HPB) to human chromosome 16q22 by in situ hybridization

Cytogenet Cell Genet. 1984;38(2):155-7. doi: 10.1159/000132050.


Human haptoglobin (Hp) is a protein that binds free hemoglobin and circulates in plasma of vertebrates as a tetrachain (alpha beta)2 structure. This study maps HPA and HPB, the genes encoding the Hp alpha and beta chains to human chromosome band 16q22 by in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, 16-18*
  • DNA / metabolism
  • Genes*
  • Haptoglobins / genetics*
  • Humans
  • Karyotyping
  • Macromolecular Substances
  • Metaphase
  • Nucleic Acid Hybridization
  • Plasmids


  • Haptoglobins
  • Macromolecular Substances
  • DNA