Pulmonary veno-occlusive disease associated with microangiopathic hemolytic anemia and chemotherapy of gastric adenocarcinoma

Med Pediatr Oncol. 1984;12(6):394-6. doi: 10.1002/mpo.2950120607.


A 68-year-old man was treated with FAM (5-fluorouracil, doxorubicin [Adriamycin], mitomycin-C) for metastic gastric adenocarcinoma. Twelve months later while in complete clinical remission, pulmonary hypertension and microangiopathic hemolytic anemia were recognized, progressed, and ended in his demise 6 months later. At necropsy, minimal residual cancer and severe pulmonary veno-occlusive disease was found. Pulmonary veno-occlusive disease may occur in association with microangiopathic hemolytic anemia and cancer chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Aged
  • Anemia, Hemolytic / chemically induced*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Doxorubicin / adverse effects
  • Fluorouracil / adverse effects
  • Humans
  • Hypertension, Pulmonary / chemically induced*
  • Male
  • Mitomycin
  • Mitomycins / adverse effects
  • Pulmonary Circulation / drug effects
  • Stomach Neoplasms / complications
  • Stomach Neoplasms / drug therapy*


  • Mitomycins
  • Mitomycin
  • Doxorubicin
  • Fluorouracil

Supplementary concepts

  • FAM protocol