Effects of peptide YY and neuropeptide Y on gastric emptying in man

Digestion. 1984;30(4):255-62. doi: 10.1159/000199117.

Abstract

Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nominal rate of 2 pmol/kg/min resulted in an increment of 59.2 +/- 7.1 pmol/1 in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 +/- 1.1 pmol/1) and had no significant effect on the rate of gastric emptying.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Colloids
  • Gastric Emptying / drug effects*
  • Gastrointestinal Hormones / blood
  • Gastrointestinal Hormones / pharmacology*
  • Humans
  • Male
  • Nerve Tissue Proteins / blood
  • Nerve Tissue Proteins / pharmacology*
  • Neuropeptide Y
  • Peptide YY
  • Peptides / blood
  • Peptides / pharmacology*
  • Technetium
  • Technetium Compounds*
  • Tin
  • Tin Compounds*

Substances

  • Colloids
  • Gastrointestinal Hormones
  • Nerve Tissue Proteins
  • Neuropeptide Y
  • Peptides
  • Technetium Compounds
  • Tin Compounds
  • technetium Tc 99m tin colloid
  • Peptide YY
  • Technetium
  • Tin