Abstract
We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. Methazolamide was next. The least tolerated drugs were ethoxzolamide, acetazolamide tablets, and dichlorphenamide.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Acetazolamide / therapeutic use
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Anorexia / chemically induced
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Carbonic Anhydrase Inhibitors / adverse effects
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Carbonic Anhydrase Inhibitors / pharmacology
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Carbonic Anhydrase Inhibitors / therapeutic use*
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Confusion / chemically induced
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Dichlorphenamide / therapeutic use
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Drug Evaluation
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Ethoxzolamide / therapeutic use
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Fatigue / chemically induced
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Glaucoma / drug therapy*
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Humans
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Intraocular Pressure / drug effects
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Methazolamide / therapeutic use
Substances
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Carbonic Anhydrase Inhibitors
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Acetazolamide
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Dichlorphenamide
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Methazolamide
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Ethoxzolamide