HLA-Dw1 and BfF as protective markers in multiple sclerosis

J Neuroimmunol. 1983 Dec;5(3):283-8. doi: 10.1016/0165-5728(83)90048-6.


The frequencies of Properdin factor B allotypes were studied in 54 multiple sclerosis patients and 58 healthy control subjects, and the association of various phenotypes with HLA-Dw1 and Dw2 antigens (found with decreased and increased frequency in MS patients, respectively) was further studied. SS genotype was found in 76% of MS patients and 63% of control subjects (n.s.) F types (FS + FF) were found to be strongly associated with HLA-Dw1 in control subjects (P less than 0.0014), whereas neither SS nor F containing types were associated with Dw2. The findings support the concept of a hypothetical MS resistance factor in the HLA gene area.

MeSH terms

  • Alleles
  • Complement Factor B / genetics*
  • Enzyme Precursors / genetics*
  • Female
  • HLA Antigens / genetics*
  • Humans
  • Male
  • Multiple Sclerosis / genetics*


  • Enzyme Precursors
  • HLA Antigens
  • Complement Factor B