A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

Nature. 1984 Jan;307(5948):237-41. doi: 10.1038/307237a0.


Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on a 98-kilobase (kb) section of the chromosome on the basis of four overlapping cosmid clones of genomic DNA. The C2 and factor B genes, less than 2 kb apart, are about 30 kb from two C4 genes separated from each other by about 10 kb.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X*
  • Complement C2 / genetics*
  • Complement C4 / genetics*
  • Complement Factor B / genetics*
  • Enzyme Precursors / genetics*
  • Genes
  • Genetic Linkage
  • Humans
  • Major Histocompatibility Complex*


  • Complement C2
  • Complement C4
  • Enzyme Precursors
  • Complement Factor B