Bronchodilator effect of delta1-tetrahydrocannabinol

Br J Clin Pharmacol. 1978 Jun;5(6):523-5. doi: 10.1111/j.1365-2125.1978.tb01667.x.


1 delta1-trans-tetrahydrocannabinol, (delta1-THC) produces bronchodilatation in asthmatic patients. 2 Administered in 62 microliter metered volumes containing 50--200 microgram by inhalation from an aerosol device to patients judged to be in a steady state, it increased peak expiratory flow rate (PEFR) and forced expiratory volume in 1 second (FEV1). 3 The rate of onset, magnitude, and duration of the bronchodilator effect was dose related.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Asthma / physiopathology
  • Bronchodilator Agents*
  • Dronabinol / pharmacology*
  • Female
  • Forced Expiratory Volume
  • Humans
  • Middle Aged
  • Peak Expiratory Flow Rate
  • Time Factors


  • Bronchodilator Agents
  • Dronabinol