PGE2 and angiogenesis

Proc Soc Exp Biol Med. 1983 Feb;172(2):214-8. doi: 10.3181/00379727-172-41548.

Abstract

The angiogenic capability of PGE2 was tested by implanting pellets of an ethylene vinyl acetate slow release polymer containing PGE2 on the chorioallantoic membrane of 8-day-old chicken embryos. Elvax pellets releasing approximately 0.2, 2.0, or 20 ng/day PGE2 were found to induce neovascular responses. In contrast, pellets releasing 2.0 or 20 ng/day of either PGA2, PGF2, or TXB2 did not appear to be angiogenic when compared with PGE2. These release rates of PGE2 are similar to those reported for a variety of tumors, activated macrophages, inflammatory exudates, and rheumatoid synovia, suggesting that PGE2 may be a key factor in various neovascular reactions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Allantoin / physiology*
  • Animals
  • Blood Vessels / drug effects
  • Blood Vessels / embryology*
  • Chick Embryo
  • Chorion / drug effects
  • Chorion / physiology*
  • Dinoprostone
  • Polyvinyls / pharmacology*
  • Prostaglandins / pharmacology
  • Prostaglandins E / pharmacology*
  • Structure-Activity Relationship

Substances

  • Polyvinyls
  • Prostaglandins
  • Prostaglandins E
  • ethylenevinylacetate copolymer
  • Allantoin
  • Dinoprostone