Perspectives on massive osteolysis. Report of a case and review of the literature

Oral Surg Oral Med Oral Pathol. 1983 Apr;55(4):331-43. doi: 10.1016/0030-4220(83)90185-8.


Massive osteolysis is a rare, chronic disease characterized by the progressive dissolution of contiguous osseous structures. There is no regeneration following the osteolysis. Pathologic fracture often leads to its discovery. The etiology and pathophysiology of the disease remain obscure. Chemo- and radiotherapeutic attempts at arresting the osteolytic process are generally unsuccessful. Bone grafting has proved disappointing, as the graft usually undergoes osteolysis. A new case of facial bone involvement in a 13-year-old boy is presented. The literature is reviewed, and the clinical experience gained from treating the disease is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Resorption / pathology*
  • Facial Bones / diagnostic imaging
  • Facial Bones / pathology*
  • Humans
  • Male
  • Osteolysis / diagnostic imaging
  • Osteolysis / pathology*
  • Osteolysis / physiopathology
  • Tomography, X-Ray Computed