Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord

Biochem Biophys Res Commun. 1983 Jul 29;114(2):533-40. doi: 10.1016/0006-291x(83)90813-6.


A new peptide, designated "neuromedin K" has been discovered and isolated from porcine spinal cord by using bioassays for a tachykinin-like effect on the contractility of smooth muscle preparation from guinea-pig ileum. Porcine neuromedin K has been identified by microsequencing as: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2. The sequence thus determined has been confirmed by synthesis. Neuromedin K has been found to have not only a remarkable sequence homology to kassinin and substance P, but also a prompt stimulant activity on guinea-pig ileum in a manner similar to that of substance P, suggesting that neuromedin K may be involved in neural transmission.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Assay
  • Chromatography, High Pressure Liquid
  • Female
  • Guinea Pigs
  • Ileum / physiology
  • Muscle Contraction / drug effects
  • Neurokinin B
  • Oligopeptides / isolation & purification*
  • Oligopeptides / pharmacology
  • Rats
  • Species Specificity
  • Spinal Cord / analysis*
  • Swine
  • Uterine Contraction / drug effects


  • Oligopeptides
  • Neurokinin B