Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy

Science. 1983 Sep 23;221(4617):1292-4. doi: 10.1126/science.6577602.

Abstract

Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Resorption*
  • Calcium
  • Cells, Cultured
  • Culture Media
  • Growth Substances / physiology*
  • Hypercalcemia / etiology*
  • Leydig Cell Tumor / complications
  • Leydig Cell Tumor / physiopathology*
  • Male
  • Neoplasm Proteins / physiology*
  • Neoplasms, Experimental / complications
  • Neoplasms, Experimental / physiopathology
  • Peptides / physiology*
  • Rats
  • Transforming Growth Factors

Substances

  • Culture Media
  • Growth Substances
  • Neoplasm Proteins
  • Peptides
  • Transforming Growth Factors
  • Calcium